I havn't had a chance to do a CTP2 install yet so don't know if its a more general issue or one specific to your site. I hope to give CTP2 a workout tomorrow night.

Hitting the URL you provided with Fiddler enabled shows that you are getting 404 (not found) HTTP return codes on all references to the DependencyHandler.axd causing both CSS style sheets and some javascript externals not to load.

I would supect that the issue is pecular to your site - most likely the ClientDependency related modifications to web.config failed to occur or the ClientDependency.Core.dll assembly did not get installed into the /bin folder - in either case the cause might be permissions related.

Were there any errors noted during the install?

Craig,

I had a few minutes this morning to try a CTP2 install. The install ran without error and when browsing to the site I did not find any problems with the skin or with loading CSS or JS. I'll try an upgrade from 6.1.4 tonight.

I would do a comparison between the web.configs of 6.1.4, 6.2.0 CTP2 fresh install, and 6.2.0 CTP2 upgraded from 6.1.4 looking in particular at the Client Dependency related nodes in the <system.webServer><handlers> section, the <system.Web><httpHandlers> section and the <clientDependency> section. If it would help, I could email you web.config files from my test installs. You may contact me at bill (at) wesnetdesigns (dot) com.

What version of IIS are you using ?
Is the AppPool set up for ASP.Net 2.0/3.5 or 4.0 ?
Did you remember to "unblock" the package downloads before extracting?