DotNetNuke latest 4.4 version contains two new features on the page settings control that helps a lot when maintaining large web sites with subsections where you tend to apply different skins and / or permissions.
On any page, when you go to "Page Settings" you will see a new option below the permissions grid.
This option, as the name explains, will copy the currently selected permissions to all descendents of the current page. Can you imagine a good use for this when trying to set some permission to a set of related pages?
On the same idea, how many times have you had to apply the same skin to a page and all descendants (so to a full section of the web site)?
"Copy design" comes to rescue!
Both options (copy permissions and copy design) will honor the current user permissions, so this will only be applied to pages where the user has edit permissions.